2023
(130) E. Koch, A. Löwen, N. Kampschulte, K. Plitzko, M. Wiebel, K.M. Rund, I. Willenberg, N.H. Schebb (2023) Beyond Autoxidation and Lipoxygenases: Fatty Acid Oxidation Products in Plant Oils, J Agric Food Chem, 71, 35, 13092-13106, /doi.org/10.1021/acs.jafc.3c02724. fulltext
(129) E. Villain, A. Chanson, M. Mainka, N. Kampschulte, P. Le Faouder, J. Bertrand-Michel, M. Brandolini-Bulon, B. Charbit, M. Musvosvi, N. Bilek, T.J. Scriba, L. QuintanaMurci, N.H. Schebb, D. Duffy, C. Gladine, the Milieu Interieur Consortium (2023) Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral and T-cell stimulation reveals new immune networks, iSCIENCE, 26, 8, 107422 , doi.org/10.1016/j.isci.2023.107422. fulltext
(128) N. Rohwer, J. Jelleschitz, A. Höhn, D. Weber, A.A. Kühl, C. Wang, R.-I. Ohno, N. Kampschulte, A. Pietzner, N.H. Schebb, K.-H. Weylandt, T. Grune (2023) Prevention of colitis-induced liver oxidative stress and inflammation in a transgenic mouse model with increased omega-3 polyunsaturated fatty acids. Redox Biology, 64: 102803, doi.org/10.1016/j.redox.2023.102803. fulltext
(127) E. Koch, A. Löwen, S. Nikolay, I. Willenberg, N. H. Schebb (2023) Trans-hydroxy, trans-epoxy and erythro-dihydroxy fatty acids increase during deep-frying. J Agric Food Chem, 71, 19, 7508–7513, doi.org/10.1021/acs.jafc.3c00964. fulltext
(126) A. Kahnt, N.H. Schebb, D. Steinhilber (2023) Formation of lipoxins and resolvins in human leukocytes. Prostag Oth Lipid M., 166: 106726, doi.org/10.1016/j.prostaglandins.2023.106726. fulltext
(125) C. G. Leineweber, M. Rabehl, A. Pietzner, N. Rohwer, M. Rothe, M. Pech, B. Sangro, R. Sharma, C. Verslype, B. Basu, C. Sengel, J. Ricke, N.H. Schebb, K.-H. Weylandt, J. Benckert (2023) Sorafenib increases Cytochrome P450 Lipid Metabolites in Patients with Hepatocellular Carcinoma. Frontiers in Pharmacology, 14: 1124214, doi.org/10.3389/fphar.2023.1124214. fulltext
(124) F. Richter, M. Friedrich, N. Kampschulte, M. Pohin, G. Alsaleh, I. Guschina, S. Wideman, E. Johnson, M. Borsa, K. Piletic, P. Hahn, H. Schipper, C. Edwards, R. Zechner, N. H. Schebb, F. Powrie, A. K. Simon (2023) Adipocyte autophagy limits gut inflammation by controlling oxylipin levels. The EMBO Journal, 42: e112202, doi.org/10.15252/embj.2022112202, fulltext
(123) K.M. Rund, N.H.Schebb (2023) Quantitative analysis of eicosanoids and other oxylipins –Investigation of oxidative stress and inflammation by means of targeted metabolomics of oxylipins in cell culture. Section in “A Practical Guide to Metabolomics Applications in Health and Disease: From Samples to Insights into Metabolism”, accepted for publication. preprint
(122) N. M. Hartung, M. Mainka, R. Pfaff, M. Kuhn, S. Biernacki, L. Zinnert, N. H. Schebb (2023) Development of a quantitative proteomics approach for cyclooxygenases and lipoxygenases in parallel to quantitative oxylipin analysis allowing the comprehensive investigation of the arachidonic acid cascade. Anal Bioanal Chem, 415(5), 1-21., doi.org/ 10.1007/s00216-022-04489-3, fulltext
(121) N. H. Schebb, D. Steinhilber (2023) What mediates the inflammation resolution? Function. doi.org/10.1093/function/zqac067, fulltext
(120) E.d. Marco, N. Kampschulte, C. Murphey, N.H. Schebb, H. Roche (2023) Oxylipin Status, Before and After LC n-3 PUFA Supplementation, Has Little Relationship with Skeletal Muscle Biology in Older Adults at Risk of Sarcopenia. Prostag Leukotr Ess M 189, 102531. doi.org/10.1016/j.plefa.2022.102531, fulltext
2022
(119) E. Koch, M. Wiebel, A. Loewen, I. Willenberg, N. H. Schebb (2022) Characterization of the Oxylipin Pattern and Other Fatty Acid Oxidation Products in Freshly Pressed and Stored Plant Oils. J Agric Food Chem doi.org/10.1021/acs.jafc.2c04987, abstract
(118) S. Janciauskiene, S. Tumpara, N. H. Schebb, F. F. R. Buettner, M. Mainka, K. Sivaraman, S. Immenschuh, V. Grau, T. Welte, B. Olejnicka (2022) Indirect effect of alpha1-antitrypsin on endotoxin-induced IL-1ß secretion from human PBMCs. Frontiers in Pharmacology, doi.org/10.3389/fphar.2022.995869, pdf
(117) E. Koch, M. Bagci, M. Kuhn, N. M. Hartung, M. Mainka, K. M. Rund, N. H. Schebb (2022) GC-MS analysis of oxysterols and their formation in cultivated liver cells (HepG2). Lipids, doi.org/10.1002/lipd.12360, pdf
(116) N. Kampschulte, T. Berking, I.E. Çelik, S.F. Kirsch, N. H. Schebb (2022) Inhibition of cytochrome P450 monooxygenase catalyzed oxylipin formation by flavonoids: Evaluation of structure-activity relationship towards CYP4F2-selective inhibitors. Eur J Med Chem, 238, 114332 abstract
(115) E. Koch, N. Kampschulte, N.H. Schebb (2022) Comprehensive analysis of fatty acid and oxylipin pattern in n3-PUFA supplements. J Agric Food Chem 70 (13) 3979–3988 abstract
(114) C. Dalle, J. Tournayre , M. Mainka, A. B.-Rasała, M. Pétéra, S. Lefèvre-Arbogast, J. Dalloux-Chioccioli, M. Deschasaux-Tanguy, L Lécuyer , E. Kesse-Guyot, L.Fezeu, S. Hercberg, P.Galan, C. Samieri, K. Zatońska, P.C.Calder, M.F. Hjorth, A. Astrup, A. Mazur, J.Bertrand, N. H. Schebb, A. Szuba, M. Touvier, J. W. Newman, C. Gladine (2022) The Plasma Oxylipin Signature Provides a Deep Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria. Int. J. Mol. Sci. 23,11688. pdf
(113) N. H. Schebb, H. Kühn, A. S. Kahnt, K. M. Rund, V. B. O’Donnell, N. Flamand, M. Peters-Golden, P.J. Jakobsson, K. H. Weylandt, N. Rohwer, R. C. Murphy, G. Geisslinger, G. A. FitzGerald, J. Hanson, C. Dahlgren, M. Wessam Alnouri, S.Offermanns, D. Steinhilber (2022) Formation, signaling and occurrence of specialized pro-resolving lipid mediators – what is the evidence so far? Frontiers in Pharmacology, 13, 838782, doi 10.3389/fphar.2022 pdf
(112) V. B O’Donnell, G. L. Milne, M. S. Nogueira, M. Giera., N. H. Schebb (2022) Quantitation of oxylipins in biological samples, focusing on plasma and urine. In: Mass Spectrometry for Lipidomics: Methods and Applications, M. Holcapek and K. Ekroos (eds.), Wiley-VCH, 2022. ISBN 978-3-527-35015-5, doi 10.1002/9783527836512 pdf, ahead of print
(111) M. Mainka, S. George, C. Angioni, R. Ebert, T. Goebel, N. Kampschulte, A. Krommes, D. Thomas, N. H. Schebb, D. Steinhilber, A. S. Kahnt (2022) On the biosynthesis of specialized pro-resolving mediator in human neutrophils and the influence of cell integrity. BBA Lipids, 1867, 159093 abstract
(110) V. B. O’Donnell, N. H Schebb, G. L. Milne, M. P. Murphy, C. P. Thomas, D. Steinhilber, S. G. Wendell, H. Kühn, P.-J. Jakkobsen, I. Blair, R.C Murphy, B. A. Freeman, A. R Brash, G. A FitzGerald (2022) Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples. Submitted for publication. Preprint doi: 10.5281/zenodo.5766267 preprint
(109) M. Misheva, K. Kotzamanis, L.C. Davies, V. J. Tyrrell, P. R. S. Rodrigues, G. A. Benavides, C. Hinz, R. C. Murphy, P.Kennedy, P. R. Taylor, M. Rosas, S. A Jones, J. E. McLaren, S. Deshpande, R. Andrews, N. H. Schebb, M. A Czubala1, M. Gurney, M. Aldrovandi, S. W. Meckelmann, P. Ghazal, V. Darley-Usmar, D. White, V. B. O’Donnell (2022) Oxylipin metabolism is controlled by mitochondrial beta-oxidation during bacterial inflammation. Nature Communications 13, 139 pdf
2021
(108) E. Marbach-Breitrück, N.Rower, C. Infante-Duarte, S. Romero-Suarez,D. Labuz, H. Machelska, L. Kutzner, N. H. Schebb, M. Rothe P. Reddanna, K. H. Weylandt, L. H. Wieler, D. Heydeck, H. Kuhn (2021) Knock-in mice expressing a 15-lipoxygenating ALOX5 mutant respond differently to experimental inflammation than reported ALOX5-/- mice. Metabolites, https//doi.org/10.3390/metabo11100698. fulltext
(107) R. N. M. Saleh, A. L. West, A. I Ostermann, N. H. Schebb, P. C Calder, A M. Minihane (2021) APOE Genotype Modifies the Plasma Oxylipin Response to Omega-3 Polyunsaturated Fatty Acid Supplementation in Healthy Individuals. Frontiers in Nutrition, doi.org/10.3389/fnut.2021.723813 fulltext
(106) E. Koch, C. Hopmann, L. F. Froehlich, N.H. Schebb (2021) Fatty acid and oxylipin concentration differ markedly between different fetal bovine serums – A cautionary note. Lipids, 56, 613-616. pdf
(105) K. L. Gützkow , J. Ebmeyer, N. Kröncke, N. Kampschulte, L. Böhmert , C. Schöne, N. H.Schebb, R. Benning, A. Bräuning , R. Maul (2021) Metabolic fate and toxicity reduction of aflatoxin B1 after uptake by edible Tenebrio molitor larvae. Food and Chemical Toxicology, 155, 112375 abstract
(104) E. Koch, M. Wiebel, C. Hopmann, N. Kampschulte, N. H. Schebb (2021) Rapid quantification of fatty acids in plant oils and biological samples by LC-MS. Anal Bioanal Chem, 43 5439-5451. pdf
(103) C. Schmöcker, H. Gottschall, K. Rund, L. Kutzner, F. Nolte, A. I. Ostermann, D. Hartmann, N. H. Schebb, K. H. Weylandt (2021) Oxylipin patterns in human colon adenomas. Prostag Leukotr Ess, 167, 102269. abstract
(102) N. Rohwer, C.Y.Chiu, C. Smyl, M. Rothe, K. M. Rund, N. H. Schebb, H. Kühn, K.-H. Weylandt (2021) Omega-3 fatty acids protect from colitis via an Alox15-derived eicosanoid. The FASEB Journal, doi.org/10.1096/fj.202002340RR pdf
(101) C. Esselun, B. Dilberger; C. V. Silaidos, E. Koch; N. H. Schebb, G. P. Eckert (2021) A Walnut Diet in Combination with Enriched Environment Affects Lipid Metabolites and Improves Cognitive Function in Aged NMRI Mice. NeuroMolecular Medicine, 23, 140-160. pdf
(100) R. G. Snodgrass, Y. Benatzy, D. Namgaladze, M. Mainka, N. H. Schebb, D. Lütjohann, B Brüne (2021) Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation. Cell Death and Differentiation, 28, 1301-1316. pdf
2020
(99) L. Kutzner, C. Esselun, N. Franke, K. Schoenfeld, G. P. Eckert, N.H. Schebb (2020) Effect of dietary EPA and DHA on murine blood and liver fatty acid profile and liver oxylipin pattern depending on high and low dietary n6-PUFA. Food & Function, Food Funct., 2020, 11, 9177 - 9191 pdf
(98) N. M. Hartung, A. I. Ostermann, S. Immenschuh, N. H. Schebb (2020) Combined targeted proteomics and oxylipin metabolomics for monitoring of the COX-2 pathway. Proteomics, doi.10.1002/pmic.201900058. pdf
(97) D. Kopczynski, A. Hentschel, C. Coman, N. H. Schebb, T. Hornemann, D. G. Mashek, N. M. Hartung, O. Shevchuk, H.-F. Schött, K. Lorenz, F. Torta, B. Burla, R. Zahedi, A. Sickmann, M. R. Kreutz, C. S. Ejsing, J. Medenbach R. Ahrends (2020) Simple Targeted Assays for Metabolic Pathways and Signaling: A Powerful Tool for Targeted Proteomics. Analytical Chemistry, 90, 13672 - 13676. pdf
(96) M. Mainka, C. Dalle, M. Pétéra, J. Dalloux-Chioccioli, N. Kampschulte, A. I. Ostermann, M. Rothe, J. Bertrand-Michel, J. W. Newman, C. Gladine, N. H. Schebb (2020) Harmonized procedures lead to comparable quantification of total oxylipins across laboratories. J Lipid Research, 2020, 61 (11), 1424 - 1436 pdf
(95) L. Kutzner, K. Goloshchapova, M. Jübermann, M. Blum, M. Rothe, S. F. Kirsch, W.-H. Schunck, H.Kühn, Nils Helge Schebb (2020) Human lipoxygenase isoforms form complex patterns of di- and tri-oxygenated compounds from eicosapentaenoic acid. BBA Lipids, 1865 (12), 158806. abstract
(94) N. Kampschulte, A. Alasmer, M. Empl, M. Krohn, P. Steinberg, N. H. Schebb (2020) Dietary polyphenols inhibit the Cytochrome P450 Monooxygenase branch of the arachidonic acid cascade with remarkable structure-dependent selectivity and potency. Agric Food Chem, 68 (34) 9235-9244 pdf
(93) R. Greite, K. Derlin, B. Hensen, A. Thorenz , S. Rong, R. Chen, M.S. Jang, J. H Bräsen, M. Meier, I. Willenberg, H. Haller, D. Panigrahy, B.D. Hammock, N.H. Schebb, F. Gueler (2020) Early antihypertensive treatment and ischemia-induced acute kidney injury. Am J Physiol-Renal, 319 (4), F563 - F570 abstract
(92) S. Hellhake, S. W. Meckelmann, M. T. Empl, K. Rentmeister, W. Wißdorf, P. Steinberg, O. J. Schmitz, T. Benter, Nils Helge Schebb (2020) Non-targeted and targeted analysis of oxylipins in combination with charge switch derivatization by ion mobility high resolution mass spectrometry. Anal Bioanal Chem 412 (23), 5743-5757. pdf
(91) E. Koch, M. Mainka, C. Dalle, A. I. Ostermann, K. M. Rund, L. Kutzner, L.-F. Froehlich, J. Bertrand-Michel, C. Gladine, N.H. Schebb (2020) Stability of oxylipins during plasma generation and long-term storage. Talanta, 217, 121074. abstract
(90) R. Ebert, R. Cumbana, C. Lehmann, L. Kutzner, A. Toewe, N. Ferreirós, M.J. Parnham, N. H. Schebb, D. Steinhilber, A.S. Kahnt (2020) Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived marcophages, BBA Lipids, 1865 (9), 158702. abstract
(89) S. Vordenbäumen, A. Sokolowski, L. Kutzner, K. M. Rund, C. Düsing, G. Chehab, J. G. Richter, R. Brinks, M. Schneider, N. H. Schebb (2020) Erythrocyte membrane polyunsaturated fatty acid profiles are associated with systemic inflammation and fish consumption in systemic lupus erythematosus: a cross-sectional study. Lupus. 29 (6), 554-559. abstract
(88) C. G. Leineweber, A. Pietzner, U. B. Blessin, A. Loew, M. Rothe, E. Schott, N. H. Schebb, K. H. Weylandt (2020) Assessment of the Effect of Sorafenib on Omega-6 and Omega-3 Epoxyeicosanoid Formation in Patients with Hepatocellular Carcinoma. International Journal of Molecular Sciences, 21, 1875. pdf
(87) K. M. Rund, F. Nolte, J. Doricic, R. Greite, R. Lichtinghagen, F. Gueler, N. H. Schebb (2020) Clinical blood sampling for oxylipin analysis – Effect of storage and pneumatic tube transport of blood on free and total oxylipin profile in human plasma and serum. Analyst, 2020, 145, 2378. pdf
(86) N. Rohwer, A. A. Kühl, A. Ostermann, N. H. Schebb, D. Zopf, F. M. McDonald, K-H. Weylandt (2020) Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis. Cancer Medicine 2020, 9; 2535-2550. pdf
(85) K.M. Rund, S. Peng, R. Greite, C. Claaßen, F. Nolte, J.-M. Galano, L. Balas, T. Durand, R. Chen, F. Guele, N. H Schebb (2020) Dietary omega-3 PUFA improved tubular function after ischemia induced acute kidney injury in mice but did not attenuate impairment of renal function. Prostag Oth Lipid M. 146, 106386. abstract
(84) E. Marbach-Breitrück, L. Kutzner, M. Rothe, R. Gurke, Y. Schreiber, P. Reddanna, N. H. Schebb, S. Stehling, L. Wieler, D. Heydeck, H. Kuhn (2020) Functional characterization of knock-in mice expressing a 12/15-lipoxygenating ALOX5 mutant instead of the 5-lipoxygenating wildetype enzyme. Antioxid Redox Signal, 32, 1-17. abstract
(83) A. I. Ostermann, E. Koch, K. M. Rund, L. Kutzner, M. Mainka, N. H. Schebb (2020) Targeting Esterified Oxylipins by LC-MS – Effect of Sample Preparation on Oxylipin Pattern. Prostag Oth Lipid M. 146, 106384 pdf
2019
(82) T. Greupner, E. Koch, L. Kutzner, A. Hahn, N.H. Schebb, J. P. Schuchardt (2019) Single-dose SDA-rich Echium oil increases plasma EPA, DPAn3 and DHA concentrations. Nutrients, 11, 2346 pdf
(81) P. Waindok, E. Janecek-Erfurth, D. Lindenwald, E. Wilk, K. Schughart, R. Geffers, J.-M. Galano, L. Balas, T. Durand, K.M. Rund, N. H. Schebb, C. Strube (2019) Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and T. cati-induced neurotoxocarosis. PLOS Neglected Tropical Diseases, 13, 1-20 pdf
(80) T. Zhou, B. Ringbeck, N. H. Schebb, J. Scherkenbeck (2019) Isolation, Total Synthesis and Quantification of Caffeoylisocitric Acid, a Characteristic Ingredient of the Superfood Amaranth. Tetrahedron, 75 (33), 4479-4485. abstract
(79) N. M. Hartung, J. Fischer, A. I.Ostermann, K. M. Rund, N. H. Schebb, U. Garscha (2019) Impact of food polyphenols on oxylipin biosynthesis in human neutrophils. BBA Lipids, 1864 (10), 1536-1544. abstract
(78) C. Gladine, A.I. Ostermann, J.W. Newman, N. H. Schebb (2019) MS-based targeted metabolomics of eicosanoids and other oxylipins: analytical and inter-individual variabilities. Free Radical Biology & Medicine, 144, 72-89 abstract
(77) S. Tewes, F. Gueler, M. Gutberlet, N. H. Schebb, K. Rund, J.T. Kielstein, V.D. VoChieu, S. Rauhut, H. Haller, F. Wacker, K. Hueper (2019) Single-dose diclofenac in healthy volunteers can cause decrease in renal perfusion measured by functional magnetic resonance imaging. J. Pharm. Pharmacol. 71(8), 1262-1270. abstract
(76) K.M. Rund, D. Heylmann, N. Seiwert, S. Wecklein, C. Oger, J.-M. Galano, T. Durand, R. Chen, F. Gueler, J. Fahrer, J. Bornhorst, N. H. Schebb (2019) Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress. Prostag Oth Lipid M. 144, 1-10. abstract
(75) L. Kutzner, K. M. Rund, A. I. Ostermann, N. M. Hartung, J.-M. Galano, L. Balas, T. Durand, M. S. Balzer, S. David, N. H. Schebb (2019) Development of an optimized LC-MS method for the detection of specialized pro-resolving mediators in biological samples. Front. Pharmacol. 10:169. pdf
(74) N. M. Hartung, M. Mainka, N. Kampschulte, A. I. Ostermanna, N. H. Schebb (2019) A strategy for validating concentrations of oxylipin standards for external calibration. Prostag Oth Lipid M, 141, 22-24. abstract
(73) K.H. Weylandt, C. Schmöcker , A. Ostermann, L. Kutzner, I. Willenberg S. Kiesler , E. Steinhagen-Thiessen, N. H. Schebb, U. Kassner (2019) Activation of lipid mediator formation due to lipoprotein apheresis. Nutrients, Nutrients 2019, 11(2), 363. pdf
(72) A. I. Ostermann, A. L. West, K. Schoenfeld, L. M. Browning, C. G. Walker, S. A. Jebb, P. C. Calder, N. H. Schebb (2019) Plasma oxylipins respond in a linear dose-response manner with increased intake of eicosapentaenoic and docosahexaeanoic acids: results from a randomized controlled trial in healthy humans. Am J Clin Nutr 2019;109:1–13. abstract
(71) L. Paloque, T. Perez-Berezo, A. Abot, J. Dalloux-Chioccioli, S. Bourgeade-Delmas, P. Le Faouder, J. Pujo, M.-A. Teste, J.-M. François, N. H. Schebb, M. Mainka, C. Rolland, C. Blanpied, G. Dietrich, J. Bertrand-Michel, C. Deraison, A. Valentin, N. Cenac (2019) Polyunsaturated fatty acid metabolites: biosynthesis in Leishmania and role in parasite/host interaction. J Lipid Res, 60, 636-647. abstract
2018
(70) A. I. Ostermann T. Greupner, L. Kutzner, N. M. Hartung, A. Hahn, J. P. Schuchardt, N. H. Schebb (2018) Intra-individual variance of human plasma oxylipin pattern: Low inter-day variability in fastened blood samples versus high variability during the day. Anal Methods, 10, 4935 – 4944 pdf
(69) C. Dalle, A. I. Ostermann, T. Konrad, C. Coudy-Gandilhon, A. Decourt, J. C. Barthélémy , F. Roche, L. Féasson, A. Mazur, D. Béchet, N. H. Schebb, C. Gladine (2018) Muscle loss associated changes of oxylipin signatures during biological aging: an exploratory study from the PROOF cohort. J Gerontol A Biol Sci Med Sci; 74(5), 608-615. abstract
(68) T. Greupner, L. Kutzner, S. Pagenkopf, H. Kohrs, A. Hahn, N. H. Schebb, J. P. Schuchardt (2018) Effects of a low and a high dietary LA/ALA ratio on long-chain PUFA concentrations in red blood cells. Food & Function, 19, 4742-4752. pdf
(67) H. Gottschall, C. Schmöcker, D. Hartmann, N. Rohwer, K. Rund, L. Kutzner, F. Nolte, A. I. Ostermann, N. H. Schebb, K. H. Weylandt (2018) Aspirin alone and combined with a statin suppresses eicosanoid formation in human colon tissue. J Lipid Res 59(5), 864-871. pdf
(66) T. Greupner, L. Kutzner, F. Nolte, A. Strangmann, H. Kohrs, A. Hahn; N. H. Schebb, J.P. Schuchardt (2018) Effects of a 12-week high-α-linolenic acid intervention on EPA and DHA concentrations in red blood cells and plasma oxylipin pattern in subjects with a low EPA and DHA status. Food & Function 9(3), 1587-1600. pdf
(65) C. Schmöcker, I. W. Zhang, S. Kiesler, U. Kassner, A. I. Ostermann, E. Steinhagen-Thiessen, N. H. Schebb, K. H. Weylandt (2018) Effect of omega-3 fatty acid supplementation on oxylipins in a routine clinical setting. Int Mol Sci 19(1) 180-185. abstract
(64) K. M. Rund, A. I. Ostermann, L. Kutzner, J.-M. Galano, C. Oger, C. Vigor; S. Wecklein, N. Seiwert, T. Durand, N. H. Schebb (2018) Development of an LC-(ESI-)-MS/MS method for the simultaneous quantification of 35 isoprostanes and isofurans derived from the major n3- and n6-PUFAs. Anal Chim Acta, 1037, 63-74. abstract
2017
(63) A. I. Ostermann, P. Waindok, M. J. Schmidt, C. Y. Chiu, C. Smyl, N. Rohwer, K. H. Weylandt, N. H. Schebb (2017) Modulation of the Endogenous Omega-3 Fatty Acid and Oxylipin Profile in vivo – A Comparison of the fat-1 Transgenic Mouse with C57BL/6 Wildtype Mice on an Omega-3 Fatty Acid Enriched Diet. PLOS-1. doi.org/10.1371/journal.pone.0184470. pdf
(62) C. Schmöcker, U. Kassner, A. I. Ostermann, S. Kiesler, E. Steinhagen-Thiessen, N. H. Schebb, K. H. Weylandt (2017) Effect of different lipid apheresis methods on plasma polyunsaturated fatty acids. Atherosclerosis-supplements, 30, 193-199. abstract
(61) J. P. Schuchardt, A. I. Ostermann, L. Stork, S. Fritsch, H. Kohrs, T. Greupner, A. Hahn, N. H. Schebb (2017) Effect of DHA supplementation on oxylipin levels in plasma and immune cell stimulated blood. Prostag Leukotr Ess, 121, 76-87. abstract
(60) A.-C. Becker, I. Willenberg, A. Springer, N. H. Schebb, P. Steinberg, C. Strube (2017) Fatty acid composition of free-living and parasitic stages of the bovine lungworm Dictyocaulus viviparus Molecular & Biochemical Parasitology, 216, 39-44. abstract
(59) A. I. Ostermann, N. H. Schebb (2017) Effects of Omega-3 Fatty Acid Supplementation on the Pattern of Oxylipins – A short review about the modulation of hydroxy-, dihydroxy-, and epoxy-fatty acids. Food & Function, 8, 2355-2367. pdf
(58) A. I. Ostermann, M. Reutzel, N. Hartung, N. Franke, L. Kutzner, K. Schoenfeld, K. H. Weylandt, G. P. Eckert , N. H. Schebb (2017) A Diet Rich in Omega-3 Fatty Acids Enhances Expression of Soluble Epoxide Hydrolase in Murine Brain. Prostag Oth Lipid M., 133, 79-87. abstract
(57) L. Kutzner, K. Goloshchapova, S. Stehling, Dagmar Heydeck, H. Kuhn, N. H. Schebb (2017) Mammalian ALOX15 orthologs exhibit pronounced dual positional specificity with docosahexanoic acid BBA Lipids, 7, 666–675 abstract
(56) S. W. Meckelmann, S. Hellhake, M. Steuck, M. Krohn, N. H. Schebb (2017) Comparison of derivatization/ionization techniques for liquid chromatography tandem mass spectrometry analysis of oxylipins. Prostag Oth Lipid M 130, 1-8. abstract
(55) L. Kutzner, A. I. Ostermann, T. Konrad, D. Riegel, J. P. Schuchardt, N. H. Schebb (2017) Lipid class specific quantitative analysis of n3-polyunsaturated fatty acid in food supplements. Agric Food Chem, 65, 139-147. abstract
(54) S. Wang, I. Willenberg, M. Krohn, T. Hecker, S. Meckelmann, C. Li, Y. Pan, N. H. Schebb, P. Steinberg, M. T. Empl (2017) Growth-inhibiting activity of resveratrol imine analogs on tumor cells in vitro. PLOS-1, doi.org/10.1371/journal.pone.017050. pdf
2016
(53) M. Steuck, S. Hellhake, N. H. Schebb (2016) Food Polyphenol Apigenin Inhibits the Cytochrome P450 Monoxygenase Branch of the Arachidonic Acid Cascade. J Agric Food Chem, 64, 8973-8976 abstract
(52) J. P. Schuchardt, A. I. Ostermann, L. Stork, L. Kutzner, H. Kohrs, T. Greupner, A. Hahn, N. H. Schebb (2016) Effects of docosahexaenoic acid supplementation on PUFA levels in red blood cells and plasma. Prostag Leukotr Ess, 115, 12-23. abstract
(51) I. Willenberg, S. Rong, N. Shushakova, F. Gueler and N. H. Schebb (2016) Characterization of changes in plasma and tissue oxylipin levels in LPS and CLP induced murine sepsis. Inflamm Res. 65, 133-142. abstract
(50) K. Moeller, A. I. Ostermann , K. Rund , S. Thoms , C. Blume , F. Stahl , A. Hahn, N. H. Schebb, J. P. Schuchardt (2016) Influence of weight reduction on blood levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and oxylipins in obese subjects. Prostag Leukotr Ess, 106, 39-49. abstract
(49) P. Nicken, A. v. Keutz, I. Willenberg, A. Ostermann, N. H. Schebb, O. Kershawb, S. Giovanninib, G. Breves and P. Steinberg (2016) Impact of dextran sulphate sodium-induced colitis on the intestinal transport of the colon carcinogen PhIP. Arch Toxicol.90(5), 1093-1102. abstract
2015
(48) I. Willenberg, A. K. Meschede, F. Güler M. S. Jang, N. Shushakova and N. H. Schebb (2015) Food polyphenols fail to cause a biologically relevant reduction of COX-2 activity. PLOS-1, 10.1371/journal.pone.0139147. pdf
(47) A. Haghikia, S. Jörg, A. Duscha, J. Berg, A. Manzel, A. Waschbisch, A. Hammer, D. Lee, C. May, N. Wilck, A. I. Ostermann, N. H. Schebb , D.A. Akkad, D.A. Grohme, M. Kleinewietfeld, J. Thöne, S. Demir, D. N. Müller , R. Gold, R. A. Linker (2015) Dietary fatty acids directly impact CNS autoimmunity via the small intestine. Immunity, 43 (4), 817-829. abstract
(46) I. Willenberg, M. Michael, J. Wonik and N. H. Schebb (2015) Investigation of the effects of soluble fibers on the absorption of resveratrol and of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) in the Caco-2 cellular model of intestinal absorption. Int J Food Sci Nutr, 66, 677-679. abstract
(45) A. I. Ostermann, J. Herbers, I. Willenberg, R. Chen, S. H. Hwang, R. Greite, C. Morisseau, F. Gueler, B. D. Hammock and N. H. Schebb (2015) Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU): Resulting drug levels and modulation of oxylipin pattern. Prostag Oth Lipid M, 121A, 131-137. abstract
(44) I. Willenberg, A. I. Ostermann, O. Kershawb, S. Giovanninib, A. v. Keutz, P. Steinberg and N. H. Schebb (2015) Effect of acute and chronic DSS induced colitis on plasma eicosanoid and oxylipin levels in the rat. Prostag Oth Lipid M, 120, 155-160. abstract
(43) I. Willenberg, A. K. Meschede and N. H. Schebb (2015) Determining COX-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin E2, D2 and thromboxane B2. J Chromatogr A 1391, 40-48. abstract
(42) P. Nicken, A. v. Keutz, I. Willenberg, L. v. Elsner, G. Hamscher, L. Vanhaecke, B. Schröder, G. Breves, N. H. Schebb and P. Steinberg (2015) Intestinal absorption and cell transforming potential of PhIP-M1, a bacterial metabolite of the heterocyclic aromatic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Toxicology Letters, 234, 92-98. abstract
(41) I. Willenberg, A. I. Ostermann and N. H. Schebb (2015) Targeted metabolomics of the arachidonic acid cascade – Current state and challenges of LC-MS analysis of oxylipins. Anal Bioanal Chem, 407, 2675–2683. abstract
(40) I. Willenberg, L. v. Elsner, P. Steinberg and N. H. Schebb (2015) Development of an online-SPE-LC-MS method for the investigation of the intestinal absorption of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) and its bacterial metabolite PHIP-M1 in a Caco-2 Transwell system. Food Chem. 166, 537–543. abstract
(39) A. I. Ostermann, I. Willenberg and N. H. Schebb (2015) Comparison of sample preparation methods for the quantitative analysis of eicosanoids and other oxylipins in plasma by means of LC-MS/MS. Anal Bioanal Chem, 407(5),1403-1414. abstract preprint, pdf
(38) I. Willenberg, M. Michael, J. Wonik, L. C. Bartel, M. T. Empl and N. H. Schebb (2015) Investigation of the absorption of resveratrol oligomers in the Caco-2 cellular model of intestinal absorption. Food Chem. 167, 245–250. abstract
(37) A. I. Ostermann, I. Willenberg, K. W. Weylandt and N. H. Schebb (2015) Development of an online-SPE-LC-MS/MS method for 26 hydroxylated polyunsaturated fatty acids as rapid targeted metabolomics approach for the LOX, CYP and autoxidation pathways of the arachidonic acid cascade. Chromatographia, 78(5), 415-428. abstract
(36) M. T. Empl, P. Kammeyer, R. Ulrich, J. F. Joseph, M. K. Parr, I. Willenberg, N. H. Schebb, W. Baumgärtner, E. Röhrdanz, C. Steffen and P. Steinberg (2015) The influence of chronic L-carnitine on the formation of preneoplastic and atherosclerotic lesions in the colon and aorta of male F-344 rats. Arch Toxicol. 89, 2079-2087. abstract
(35) R. Maul, B. Warth, N.H. Schebb, R. Krska, M. Koch and M. Sulyok (2015) In vitro glucuronidation kinetics of deoxynivalenol by human and animal microsomes and recombinant human UGT enzymes. Arch Toxicol. 89, 949-960. abstract
2014
(34) A. I. Ostermann, M. Müller, I. Willenberg and N. H. Schebb (2014) Determining the fatty acid composition in plasma and tissues as fatty acid methyl esters by gas chromatography – A comparison of different derivatization and extraction procedures. Prostag Leukotr Ess. 91, 235-241. abstract preprint, pdf
(33) N. H. Schebb, A. I. Ostermann, J. Yang, B. D. Hammock, A. Hahn and J. P. Schuchardt (2014) Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins. Prostag Oth Lipid M, 113-115, 21-29. abstract
(32) J. P. Schuchardt, I. Schneider, I. Willenberg, J. Yang, B. D. Hammock, A. Hahn and N. H. Schebb (2014) Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA. Prostag Oth Lipid M. 109-111, 23-31. abstract
(31) N. H. Schebb, J. B. Muvvala, D. Morin, A. R. Buckpitt, B. D. Hammock and R. H. Rice (2014) Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Dispos. 42 (7),1098-1102. abstract
(30) J. P. Schuchardt, S. Schmidt, G. Kressel, H. Dong, I. Willenberg, B. D. Hammock, A. Hahn and N. H. Schebb (2014) Modulation of blood oxylipin levels by long-chain omega-3 fatty acid supplementation in hyper- and normolipidemic men. Prostag Leukotr Ess. 90, 27-37. abstract
2013
(29) S. Stolte, S. Steudte, I. Willenberg, N. H. Schebb and P. Stepnowski (2013) Ecotoxicity of artificial sweeteners and stevioside. Environ Int. 60, 123-127. abstract
(28) J. P. Schuchardt, S. Schmidt, G. Kressel, H. Dong, I. Willenberg, B. D. Hammock, A. Hahn and N. H. Schebb (2013) Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. Prostag Leukotr Ess. 89, 19-29. abstract
(27) D. Falck, N. H. Schebb, S. Prihatiningtyas, J. Zhang, F. Heus, C. Morisseau, J. Kool, B. D. Hammock and W. M. A. Niessen (2013) Development of On-line Liquid Chromatography-Biochemical Detection for Soluble Epoxide Hydrolase Inhibitors in Mixtures. Chromatographia. 76, 13-21. abstract
2012
(26) R. Maul, B. Warth, J. S. Kant, N. H. Schebb, R. Krska, M. Koch and M. Sulyok (2012) Investigation of the hepatic glucuronidation pattern of the Fusarium mycotoxin deoxynivalenol in various species. Chem ResTox. 25, 2715-2717 abstract
(25) G. Cherednichenko, R. Zhang, R. A. Bannister, V. Timofeyev, N. Li, E. B. Holland-Fritsch, W. Feng, G. C. Barrientos, N. H. Schebb, B. D. Hammock, K. G. Beam, N. Chiamvimonvat and I. N. Pessah (2012) Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U S A. 109 (35), 14158-14163. pdf
(24) I. Willenberg, W. Brauer, M. T. Empl and N. H. Schebb (2012) Development of a rapid LC-UV Method for the Investigation of chemical and metabolic Stability of Resveratrol Oligomers. J Agric Food Chem. 60 (32), 7844-7850. abstract
(23) B. Inceoglu, K. M. Wagner, J. Yang, A. Bettaieb, N. H. Schebb, S. H. Hwang, C. Morisseau, F. Haj and B. D. Hammock (2012) Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proc Natl Acad Sci U S A. 109 (28), 11390-11395 pdf
(22) N. H. Schebb, B. Buchholz, B. D. Hammock and R. H. Rice (2012) Metabolism of the Antibacterial Triclocarban by Human Epidermal Keratinocytes to Yield Protein Adducts? J Biochem Mol Toxic. 26 (6), 230-234. abstract
(21) A. Eißing, D. Fischer, A. Baumann, N. H. Schebb, U. Karst, K. Rose, S. Klumpp and J. Krieglstein (2012) Acetylcholine content and viability of cholinergic neurons are influenced by the activity of protein histidine phosphatase. BMC Neuroscience 13:31. pdf
(20) C. Morisseau, N. H. Schebb, H. Dong, A. Ulu, P. A. Aronov and B. D. Hammock (2012) Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem Bioph Res Co. 419 (4), 796-800. pdf
(19) N. H. Schebb, K. C. Ahn, H. Dong, S. J. Gee and B. D. Hammock (2012) Whole blood is the sample matrix of choice for monitoring systemic triclocarban levels. Chemosphere. 87 (7), 825-827 pdf
(18) K. C. Ahn, T. Kasagami, H. J. Tsai, N. H. Schebb, T. Ogunyoku, S. J. Gee, T. M. Young and B. D. Hammock (2012) An Immunoassay to Evaluate Human/Environmental Exposure to the Antimicrobial Triclocarban. Environ Sci Techno. 46 (1), 374-381. pdf
(17) N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock (2012) In vitro glucuronidation of the antibacterial triclocarban and its oxidative metabolites. Drug Metab Dispos. 40 (1), 25-31. abstract
2011
(16) N. H. Schebb, I. Flores, T. Kurobe, B. Franze, A. Ranganathan, B. D. Hammock and S. Teh (2011) Bioconcentration, Metabolism and Excretion of Triclocarban in Larval Qurt Medaka (Oryzias latipes). Aquat Toxicol. 105, 448-454. pdf
(15) N. H. Schebb, M. Huby, S. H. Hwang, C. Morisseau, and B. D. Hammock (2011) Development of an Online-SPE-LC-MS Based Assay using Endogenous Substrate for Investigation of Soluble Epoxide Hydrolase (sEH) Inhibitors. Anal Bioanal Chem. 400 (5), 1359-1366. pdf
(14) B. Inceoglu, K. Wagner, N. H. Schebb, C. Morisseau, S. L. Jinks, C. Hegedus, A. Ulu, R. Brosnan, A. L. Morrow and B. D. Hammock (2011) Epoxy-fatty acid produced antinociception is driven by pain and elevated cAMP. Proc Natl Acad Sci U S A. 108, (12), 5093-5097. pdf
(13) N. H. Schebb, B. Inceoglu, K. C. Ahn, C. Morisseau, S. Gee and B. D. Hammock (2011) Investigation of human exposure to triclocarban after showering, and preliminary evaluation of its biological effects. Environ Sci Techno. 45 (7), 3109-3115. pdf
(12) N. H. Schebb, B. Inceoglu, K. Wagner, T. Rose and B. D. Hammock (2011) Development of an ultra fast online-solid phase extraction (SPE) liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) based approach for the determination of drugs in pharmacokinetic studies. Anal Methods. 3, 420-428. pdf
2010
(11) A. Baumann, W. Lohmann, T. Rose, K. C. Ahn, B. D. Hammock, U. Karst and N. H. Schebb (2010) Electrochemistry-mass spectrometry unveils the formation of reactive triclocarban (TCC) metabolites. Drug Metab Dispos. 38, 2130-2138. pdf
(10) M. Siemerink, N. H. Schebb, A. Liesener, M. Vogel, H. Hayen and U. Karst (2010) Development of a fast LCMS-based Screening-Method for Angiotensin-Converting-Enzyme (ACE)-Inhibitors in complex natural mixtures like snake venom. Rapid Commun Mass Spectrom. 24, 687-697. abstract
(9) A. Braune, S. E. Kulling, R. Maul, N. H. Schebb and M. Blaut (2010) The red clover isoflavone irilone is largely resistant to degradation by the human gut microbiota. Mol Nutr Food Res. 54, 929-938. abstract
2009
(8) N. H. Schebb, D. Falck, E-M. Hein, U. Karst and H. Hayen (2009) A fast LC-ESI-MS Method for Monitoring Phospholipase A2 Activity. J Chromatogr A. 1216, 5249-5255. abstract
(7) N. H. Schebb, T. Vielhaber, A. Jousset and U. Karst (2009) Development of a Liquid Chromatography-Based Screening Methodology for Proteolytic Enzyme Activtiy. J Chromatogr A. 1216, 4407-4415. abstract
(6) N. H. Schebb, H. Faber, R. Maul, F. Heus, J. Kool, H. Irth and U. Karst (2009) Analysis of Glutathione Adducts of Patulin by Means of Liquid Chromatography (HPLC) with Biochemical Detection (BCD) and Electrospray Ionization Tandem Mass Spectrometry (ESI-MS/MS). Anal Bioanal Chem. 394, 1361-1373. abstract
2008
(5) N. H. Schebb, F. Heus, T. Saenger, H. Irth, U. Karst and J. Kool (2008) Development of a Countergradient Parking System for Gradient Liquid Chromatography with Online Biochemical Detection of Serine Protease Inhibitors. Anal Chem. 80 (17), 6764-6772. abstract
(4) N. H. Schebb, D. Fischer, E-M. Hein, H. Hayen, J. Krieglstein, S. Klumpp and U. Karst (2008) Fast sample preparation and liquid chromatography-tandem mass spectrometry method for assaying cell lysate acetylcholine. J Chromatogr A. 1183, 100-107. abstract
(3) R. Maul, N. H. Schebb and S. E. Kulling (2008) Application of LC and GC hyphenated with mass spectrometry as tool for characterization of unknown derivatives of isoflavonoids. Anal Bioanal Chem. 391, 239-250. abstract
2007
(2) E. Pfeiffer, N. H. Schebb, J. Podlech and M. Metzler (2007) Novel oxidative in vitro metabolites of the mycotoxins alternariol and alternariol methyl ether. Mol Nutr Food Res. 51, 307-316. abstract
(1) A. Liesener, A. M. Perchuc, R. Schöni, N. H. Schebb, M. Wilmer and U. Karst (2007) Screening of acetylcholinesterase inhibitors in snake venom by electrospray mass spectrometry. Pure Appl Chem. 79 (12), 2339-2349. pdf
