Fakultät für Mathematik und Naturwissenschaften

Peer-Reviewed

PEER REVIEWED ARTICLES

(1) V. Michaelis, L. Aengenheister, M. Tuchtenhagen, J. Rinklebe, F. Ebert, T. Schwerdtle, T. Buerki-Thurnherr, J. Bornhorst, Differences and Interactions in Placental Manganese and Iron Transfer across an In Vitro Model of Human Villous Trophoblasts. Int J Mol Sci. 2022 Mar 18;23(6):3296. doi: 10.3390/ijms23063296.

(2) M. Aschner , A. V. Skalny, T. Ke, J. B. da Rocha, M. M. Paoliello, A. Santamaria, J. Bornhorst, L. Rongzhu, A. A. Svistunov, A. B. Djordevic, A. A. Tinkov AA, Hydrogen sulfide (H2S) signaling as a protective mechanism against endogenous and exogenous neurotoxicants, Curr Neuropharmacol. 2022 Mar 2.

(3) P. Chen, H. Cheng, F. Zheng, S. Li, J. Bornhorst , B. Yang, K. H. Lee, T. Ke, Y. Li, T. Schwerdtle, X. Yang, A. B. Bowman, M. Aschner , BTBD9 attenuates manganese induced oxidative stress and neurotoxicity by regulating insulin growth factor signaling pathway, Hum Mol Genet. 2022 Feb 3;ddac025.

(4) M. M Nicolai, B. Witt, S. Friese, V. Michaelis, L. Hölz-Armstrong, M. Martin, F. Ebert , T. Schwerdtle, J. Bornhorst, Mechanistic studies on the adverse effects of manganese overexposure in differentiated LUHMES cells, Food Chem Toxicol . 2022 Jan 19;161:112822.

(5) N. Crawford, M. Martell, T. Nielsen, B.l Khalil, F. Imtiaz, E. Nguidjo, J. L. Newell-Caito, J. Bornhorst, T. Schwerdtle, S. W. Caito, Methylmercury-Induced Metabolic Alterations in Caenorhabditis elegans is Diet Dependent, Toxics 2021 Nov 2;9(11):287.

(6) M. M. Nicolai, A. K. Weishaupt, J. Baesler, V. Brinkmann, A. Wellenberg, N. Winkelbeiner, A. Gremme, M. Aschner, G. Fritz, T. Schwerdtle, J. Bornhorst, Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans, Int. J. Mol. Sci. 2021, 22, 10905.

(7) A. Wellenberg, V. Brinkmann, J. Bornhorst, N. Ventura, S. Honnen, G. Fritz, Cisplatin-induced neurotoxicity involves the disruption of serotonergic neurotransmission, Pharmacol Res. 2021 Sep 30:105921.

(8) M. M. Nicolai , B. Witt , A. Hartwig, T. Schwerdtle, J. Bornhorst, A fast and reliable method for monitoring genomic instability in the model organism Caenorhabditis elegans, Arch Toxicol. 2021 Oct;95(10):3417-3424.

(9) A. M. Varão, J. D. S. Silva, L. O. Amaral, L. L. P. Aleixo, A. Onduras, C. S. Santos, L. P. D. Silva, D. E. Ribeiro, J. L. L. Filho, J. Bornhorst, M. Stiboller, T. Schwerdtle, L. C. Alves, F. A. A. Soares, P. Gubert, Toxic effects of thallium acetate by acute exposure to the nematode C. elegans, J Trace Elem Med Biol. 2021 Aug 25;68:126848.

(10) J. Scholz, P. O. Helmer, M. M. Nicolai, J. Bornhorst, H. Hayen, Profiling of sphingolipids in Caenorhabditis elegans by two-dimensional multiple heart-cut liquid chromatography - mass spectrometry, J Chromatogr A. 2021 Aug 18;1655:462481.

(11) O. M. Ijomone, J. D. Iroegbu, M. Aschner, J. Bornhorst, Impact of environmental toxicants on p38- and ERK-MAPK signaling pathways in the central nervous system, Neurotoxicology. 2021 Aug 10;86:166-171.

(12) S. Fudickar, E. J. Nustede, E. Dreyer, J. Bornhorst, Mask R-CNN Based C. Elegans Detection with a DIY Microscope, Biosensors (Basel). 2021 Jul 30;11(8):257.

(13) V. Wandt, N. Winkelbeiner, K. Lossow, J. F. Kopp, M. Schwarz , W. Alker, M. M. Nicolai, L. Simon, C. Dietzel, B. Hertel, G. Pohl, F. Ebert, L. Schomburg, J. Bornhorst, H. Haase, A. P. Kipp, T. Schwerdtle, Ageing-associated effects of a long-term dietary modulation of four trace elements in mice, Redox Biol. 2021 Jul 27;46:102083.

(14) A. Wellenberg, L. Weides, J. Kurzke, T. Hennecke, J. Bornhorst, B. Crone, U. Karst, V. Brinkmann, G. Fritz, S. Honnen, Use of C. elegans as a 3R-compliant in vivo model for the chemoprevention of cisplatin-induced neurotoxicity, Exp Neurol. 2021 Mar 20;341:113705.

(15) P. Chen, J. Bornhorst, S. Patton, K. Bagai, R. Nitin, M. Miah, D. J. Hare, K. Kysenius, P. J. Crouch, L. Xiong, G. A. Rouleau, T. Schwerdtle, J. Connor, M. Aschner, A. B. Bowman, A. S. Walters, A potential role for zinc in restless legs syndrome, Sleep. 2021 Apr 9;44(4):zsaa236.

(16) P. Morcillo, H. Cordero, O. M. Ijomone, A. Ayodele, J. Bornhorst, L. Gunther, F. P. Macaluso, A. B. Bowman, M. Aschner, Defective mitochondrial dynamics underlie manganese-induced neurotoxicity, Mol Neurobiol. 2021 Mar 5.doi: 10.1007/s12035-021-02341-w.

(17) J. Baesler, V. Michaelis, M. Stiboller, H. Haase, M. Aschner, T. Schwerdtle, S. R. Sturzenbaum, J. Bornhorst, Nutritive manganese and zinc overdosing in aging C. elegans result in a metallothionein-mediated alteration in metal homeostasis, Mol Nutr Food Res. 2021 Feb 28;e2001176.

(18) V. K. Wandt, N. Winkelbeiner, J. Bornhorst, B. Witt, S. Raschke, L. Simon, F. Ebert, A. P. Kipp, T. Schwerdtle, A matter of concern - Trace element dyshomeostasis and genomic stability in neurons, Redox Biol. 2021 Jan 24;41:101877.

(19) E. Drobyshev, S. Raschke, R. A. Glabonjat, J. Bornhorst, F. Ebert, D. Kuehnelt, T. Schwerdtle, Capabilities of selenoneine to cross the in vitro blood-brain barrier model, Metallomics. 2021 Jan 21;13(1):mfaa007.

(20) E. C. Kuhn, M. T. Jacques, D. Teixeira, S. Meyer, T. Gralha, R. Roehrs, S. Camargo, T. Schwerdtle, J. Bornhorst, D. S. Ávila, Ecotoxicological assessment of Uruguay River and affluents pre- and post-pesticides' application using Caenorhabditis elegans for biomonitoring, Environ Sci Pollut Res Int. 2021 Jan 7. doi: 10.1007/s11356-020-11986-4.

(21) P. Chen, J. Bornhorst, S. Patton, K. Bagai, R. Nitin, M. Miah, D. J. Hare, K. Kysenius, P. J. Crouch, L. Xiong, G. A. Rouleau, T. Schwerdtle, J- Connor, M. Aschner, A. B. Bowman, A. S. Walters, A potential role for Zinc in Restless Legs Syndrome, Sleep. 2020 Nov 11:zsaa236. doi: 10.1093/sleep/zsaa236.

(22) P. O. Helmer, M. M. Nicolai, V. Schwantes, J. Bornhorst, H. Hayen, Investigation of cardiolipin oxidation products as a new endpoint for oxidative stress in C. elegans by means of online two-dimensional liquid chromatography and high-resolution mass spectrometry, Free Radic Biol Med. 2020 Oct 27:S0891-5849(20)31293-4.

(23) M. Aschner, T. T. Nguyen, A. I. Sinitskii, A. Santamaría, J. Bornhorst, O. P. Ajsuvakova, J. B. T. da Rocha, A. V. Skalny, A. A. Tinkov, Isolevuglandins (isoLGs) as toxic lipid peroxidation byproducts and their pathogenetic role in human diseases, Free Radic Biol Med. 2020 Oct 21:S0891-5849(20)31298-3.

(24) A. V. Skalny, T. R. R. Lima, T. Ke, J. C. Zhou, J. Bornhorst, S. I. Alekseenko, J. Aaseth, O. Anesti, D. A. Sarigiannis, A. Tsatsakis, M. Aschner, A. A. Tinkov, Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases, Food Chem Toxicol. 2020 Oct 16;146:111809.

(25) T. Ke, A. Santamaria, J. B. T. Rocha, A. Tinkov, J. Bornhorst, A. B. Bowman, M. Aschner, Cephalic Neuronal Vesicle Formation is Developmentally Dependent and Modified by Methylmercury and sti-1 in Caenorhabditis elegans, Neurochem Res. 2020 Oct 10., doi: 10.1007/s11064-020-03142-8.

(26) N. Winkelbeiner, V. K. Wandt, F. Ebert, K. Lossow, E. E. Bankoglu, M. Martin, A. Mangerich, H. Stopper, J. Bornhorst, A. P. Kipp, T. Schwerdtle, A Multi-Endpoint Approach to Base Excision Repair Incision Activity Augmented by PARylation and DNA Damage Levels in Mice: Impact of Sex and Age, Int J Mol Sci. 2020 Sep 9;21(18):6600.

(27) E. Pajarillo, J. Jr. Johnson, A. Rizor, I. Nyarko-Danquah, G. Adinew, J. Bornhorst, M. Stiboller, T. Schwerdtle, D. S. Son, M. Aschner, E. Lee, Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity, J Biol Chem. 2020 Sep 6;jbc.RA120.015552.

(28) L. de O. Amaral, V. S. Lima, S.M. Soares, J. Bornhorst, S. S. Lemos, C. C. Gatto, R. A. Burrow, P. Gubert, Synthesis, structural characterization and evaluation of the chelating potential in C. elegans involving complexes of mercury (II) with Schiffbases derived from amino acids, Journal of Organometallic Chemistry, 2020, j.jorganchem.2020.121500

(29) T. Ke, A. Santamaría, A. .A Tinkov, J. Bornhorst, M. Aschner, Generating Bacterial Foods in Toxicology Studies With Caenorhabditis Elegans, Curr Protoc Toxicol. 2020 Jun;84(1):e94.

(30) T. Ke, J. Bornhorst, T. Schwerdtle, A. Santamaría, F. A. A. Soare , J. B. T. Rocha, M. Farina, A. B. Bowman, M. Aschner, Therapeutic Efficacy of the N,N' Bis-(2-Mercaptoethyl) Isophthalamide Chelator for Methylmercury Intoxication in Caenorhabditis elegans. Neurotox Res. 2020 Mar 31. doi: 10.1007/s12640-020-00194-0.

(31) C. A. Taylor, K. Tuschl, M. M. Nicolai, J. Bornhorst, P. Gubert, A. M. Varão, M. Aschner, D. R. Smith, S. Mukhopadhyay, Maintaining Translational Relevance in Animal Models of Manganese Neurotoxicity. J Nutr. 2020 Mar 25. doi: 10.1093/jn/nxaa066.

(32) J. Bornhorst, F. Ebert, S. Meyer, V. Ziemann, C. Xiong, N. Guttenberg, A. Raab, J. Baesler, M. Aschner, J. Feldmann, K. A. Francesconi, G. Raber, T.Schwerdtle, Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans, Metallomics, 2020 doi.org/10.1039/D0MT00039F

(33) C. Neumann, J. Baesler, G. Steffen, M. M. Nicolai, T. Zubel, M. Aschner, A. Bürkle, A. Mangerich, T. Schwerdtle, J. Bornhorst, The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans. J Trace Elem Med Biol 2020, 57:21-27

(34) M. T. Jacques, J. Bornhorst, M. V. Soares, T. Schwerdtle, S. Garcia, D. S. Ávila, Reprotoxicity of glyphosate-based formulation in Caenorhabditis elegans is not due to the active ingredient only. Environ Pollut. 2019 Jun 27;252(Pt B):1854-1862. doi: 10.1016/j.envpol.2019.06.099

(35) J. Baesler, J. Kopp, G. Pohl, M. Aschner, H. Haase, T. Schwerdtle, J. Bornhorst, Zn homeostasis in genetic models of Parkinson's disease in Caenorhabditis elegans. J Trace Elem Med Biol 2019 55: 44-49.

(36) K. M. Rund, D. Heylmann, N. Seiwert, S. Wecklein, C. Oger, J. M. Galano, T. Durand, R. Chen, F. Gueler, J. Fahrer, J. Bornhorst, N. H. Schebb, Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress. Prostaglandins Other Lipid Mediat. 2019 Apr 19:106334. doi: 10.1016/j.prostaglandins.2019.04.004.

(37) I. Rohn, S. Raschke, M. Aschner, S. Tuck, D. Kuehnelt, A. Kipp, T. Schwerdtle, J. Bornhorst, Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems. Mol Nutr Food Res. 2019 May;63(9):e1801304. doi: 10.1002/mnfr.201801304.

(38) J. Bornhorst, E. J. Nustede, S. Fudickar, Mass Surveilance of C. elegans-Smartphone-Based DIY Microscope and Machine-Learning-Based Approach for Worm Detection. Sensors (Basel) 2019 Mar 26;19(6).

(39) J. A. Ruszkiewicz, G. Teixeira de Macedo, A. Miranda-Vizuete, A. B. Bowman, J. Bornhorst, T. Schwerdtle, F. A. Antunes Soares, M. Aschner, Sex-Specific Response of Caenorhabditis elegans to Methylmercury Toxicity. Neurotox Res. 2019 Jan, 35, 1, 208-216.

(40) T. V. Peres, K. J. Horning, J. Bornhorst, T. Schwerdtle, A. B. Bowman, M. Aschner, Small Molecule Modifiers of In Vitro Manganese Transport Alter Toxicity In Vivo. Biol Trace Elem Res. 2018 Sep 28, doi: 10.1007/s12011-018-1531-7.

(41) J. A. Ruszkiewicz, G. Teixeira de Macedo, A. Miranda-Vizuete, J. B. Teixeira da Rocha, A. B. Bowman, J. Bornhorst, T. Schwerdtle, M. Aschner, The cytoplasmic thioredoxin system in Caenorhabditis elegans affords protection from methylmercury in an age-specific manner. Neurotoxicology. 2018 Sep, 68, 189-202.

(42) P. Chen, J. Bornhorst, M. Diana Neely, D. S. Avila, Mechanisms and Disease Pathogenesis Underlying Metal-Induced Oxidative Stress. Oxid Med Cell Longev. 2018 Sep 18, 2018, 7612172.

(43) T. V. Peres, L. P. Arantes, M. R. Miah, J. Bornhorst, T. Schwerdtle, A. B. Bowman, R. B. Leal, M. Aschner, Role of Caenorhabditis elegans AKT-1/2 and SGK-1 in Manganese Toxicity, Neurotox Res. 2018 Jun 7. doi: 10.1007/s12640-018-9915-1.

(44) B. Ferrer, T. V. Peres, A. A. Dos Santos, J. Bornhorst, P. Morcillo, C. L. Gonçalves, M. Aschner, Methylmercury Affects the Expression of Hypothalamic Neuropeptides That Control Body Weight in C57BL/6J Mice, Toxicol Sci., 2018, 163, 2, 557-568.

(45) I. Rohn, T. A. Marschall, N. Kroepfl, K. B. Jensen, M. Aschner, S. Tuck, D. Kuehnelt, T. Schwerdtle, J. Bornhorst, Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans, Metallomics, 2018, 10, 6, 818-827.

(46) P. Gubert , B. Puntel , T. Lehmen, J. P. Fessel, P. Cheng, J. Bornhorst, L. S. Trindade, D. S. Avila , M. Aschner, F. A. A. Soares, Metabolic effects of manganese in the nematode Caenorhabditis elegans through DAergic pathway and transcription factors activation, Neurotoxicology, 2018, 67, 65-72.

(47) P. Chen, J. Bornhorst, M. Aschner, Manganese metabolism in humans, Frontiers in bioscience 2018, 23, 1655-1679.

(48) K. Nowotny, J. P. Castro, M. Hugo, S. Braune, D. Weber, M. Pignitter, V. Somoza, J. Bornhorst, T. Schwerdtle, T. Grune, Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts, Free radical biology & medicine 2018, 120, 102-113.

(49) S. M. Müller, F. Ebert, J. Bornhorst, H. J. Galla, K.A. Francesconi, T. Schwerdtle, Arsenic-containing hydrocarbons disrupt a model in vitro blood-cerebrospinal fluid barrier, Journal of trace elements in medicine and biology 2018, DOI 10.1016/j.jtemb.2018.01.020.

(50) S. M. Müller, F. Ebert, G. Raber, S. Meyer, J. Bornhorst, S. Hüwel, H.J. Galla, K.A. Francesconi, T. Schwerdtle, Effects of arsenolipids on in vitro blood-brain barrier model, Archives of toxicology 2018, 92, 823-832.

(51) J. Bornhorst, A. P. Kipp, H. Haase, S. Meyer, T. Schwerdtle, The crux of inept biomarkers for risks and benefits of trace elements, Trends in Analytical Chemistry 2017, Manuscript in Press, doi: 10.1016/j.trac.2017.11.007

(52) J. Strehlau, T. Weber, C. Lürenbaum, J. Bornhorst, H. J. Galla, T. Schwerdtle, M. Winter, S. Nowak, Towards quantification of toxicity of lithium ion battery electrolytes - development and validation of a liquid-liquid extraction GC-MS method for the determination of organic carbonates in cell culture materials, Anal Bioanal Chem. 2017, Aug 3. doi: 10.1007/s00216-017-0549-6.

(53) B. Witt, J. Bornhorst, H. Mitze, F. Ebert, S. Meyer, K. A. Francesconi, T. Schwerdtle, Arsenolipids exert less toxicity in a human neuron astrocyte co-culture as compared to the respective monocultures, Metallomics 2017, 9, 5, 442-446.

(54) T. A. Marschall, N. Kroepfl, K. B. Jensen, J. Bornhorst, B. Meermann, D. Kuehnelt, T. Schwerdtle, Tracing cytotoxic effects of small organic Se species in human liver cells back to total cellular Se and Se metabolites, Metallomics 2017, 9, 3, 268-277.

(55) M. Aschner, C. Palinski, M. Sperling, U. Karst, T. Schwerdtle, J. Bornhorst, Imaging metals in Caenorhabditis elegans, Metallomics 2017, 9, 4, 357-364.

(56) H. Lohren, J. Bornhorst, R. Fitkau, G. Pohl, H. J. Galla and T. Schwerdtle, Effects on and transfer across the blood-brain barrier in vitro - Comparison of organic and inorganic mercury species, BMC pharmacology & toxicology 2016, 17, 63.

(57) T. A. Marschall, J. Bornhorst, D. Kuehnelt, T. Schwerdtle, Differing cytotoxicity and bioavailability of selenite, methylselenocysteine, selenomethionine, selenosugar 1 and trimethylselenonium ion and their underlying metabolic transformations in human cells, Molecular nutrition & food research 2016, 60, 2622-2632.

(58) A. Henze, T. Homann, I. Rohn, M. Aschner, C. D. Link, B. Kleuser, F. J. Schweigert, T. Schwerdtle, J. Bornhorst, Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin, Scientific reports 2016, 6, 37346.

(59) D. S. Avila, A. Benedetto, C. Au, J. Bornhorst, M. Aschner, Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans, BMC pharmacology & toxicology 2016, 17, 54.

(60) P. Gubert, B. Puntel, T. Lehmen, J. Bornhorst, D. S. Avila, M. Aschner, F. A. A. Soares , Reversible reprotoxic effects of manganese through DAF-16 transcription factor activation and vitellogenin downregulation in Caenorhabditis elegans, Life sciences 2016, 151, 218-223.

(61) T. V. Peres, H. Eyng, S. C. Lopes, D. Colle, F. M. Gonçalves, D. K. Venske, M. W. Lopes, J. Ben, J. Bornhorst, T. Schwerdtle, M. Aschner, M. Farina, R. D. Prediger, R. B. Leal, Developmental exposure to manganese induces lasting motor and cognitive impairment in rats, Neurotoxicology 2015, 50, 28-37.

(62) F. Schumacher, S. Chakraborty, B. Kleuser, E. Gulbins, T. Schwerdtle, M. Aschner, J. Bornhorst, Highly sensitive isotope–dilution liquid–chromatography–electrospray ionization tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans, Talanta 2015, 144, 71-79.

(63) B. Crone, M. Aschner, T. Schwerdtle, U. Karst, J. Bornhorst, Elemental bioimaging of Cisplatin in Caenorhabditis elegans by LA-ICPMS, Metallomics 2015, 7, 7, 1189-95

(64) S. Chakraborty, P. Chen, J. Bornhorst, T. Schwerdtle, F. Schumacher, B. Kleuser, A. B. Bowman, M. Aschner, Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans, Metallomics 2015, 7, 5, 847-56.

(65) H. Lohren, J. Bornhorst, H. J. Galla, T. Schwerdtle, The blood-cerebrospinal fluid barrier - first evidence for an active transport of organic mercury compounds out of the brain, Metallomics 2015, 7, 10, 1420-30.

(66) K. K. Kumar, C. R. Goodwin, M. A. Uhouse, J. Bornhorst, T. Schwerdtle, M. Aschner, J. A. McLeanb, A. B. Bowman, Untargeted metabolic profiling identifies interactions between Huntington’s disease and neuronal manganese status, Metallomics 2015, 7, 2, 263-270.

(67) P. Chen, M. R. DeWitt, J. Bornhorst, F. A. Soares, S. Mukhopadhyay, A. B. Bowman and M. Aschner, Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease, Metallomics 2015, 7, 2, 289-98.

(68) S. Cramer, S. Tacke, J. Bornhorst, A. K. Sachan, J. Klingauf, T. Schwerdtle, H.-J. Galla. The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro. J Nanomed Nanotechnol 2014, 5, 5. DOI: 10.4172/2157-7439.1000225.

(69) I. Pieper, C. A. Wehe, J. Bornhorst, F. Ebert, L. Leffers, M. Holtkamp, P. Höseler, T. Weber, A. Mangerich, A. Bürkle, U. Karst, T. Schwerdtle, Mechanisms of Hg species induced toxicity in cultured human astrocytes: genotoxicity and DNA-damage response. Metallomics 2014, 6, 662-671.

(70) S. Große Brinkhaus, J. Bornhorst, S. Chakraborty, C. A. Wehe, R. Niehaus, O. Reifschneider, M. Aschner, U. Karst, Elemental bioimaging of manganese uptake in C. elegans. Metallomics 2014, 6, 617-621.

(71) J. Bornhorst §, S. Chakraborty §, S. Meyer, H. Lohren, S. Große Brinkhaus, A. L. Knight, K. A. Caldwell, G. A. Caldwell, U. Karst, T. Schwerdtle, A. Bowmann, M. Aschner , The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of alpha-synuclein in C. elegans. Metallomics 2014, 6, 476-490. § Both authors contributed equally to this study

(72) S. Chakraborty, J. Bornhorst, T. T. Nguyen, M. Aschner, Oxidative Stress Mechanisms Underlying Parkinson’s Disease-Associated Neurodegeneration in C. elegans. Int. J. Mol. Sci. 2013 14, 11, 23103-28.

(73) P. Chen, E. J. Martinez-Finley, J. Bornhorst, S. Chakraborty, M. Aschner, Metal-induced neurodegeneration in C. elegans. Front. Aging Neurosci. 2013 May 20, 5, 18.
doi: 10.3389/fnagi.2013.00018. eCollection 2013.

(74) J. Bornhorst, S. Meyer, T. Weber, C. Böker, T. Marschall, A. Mangerich, S. Beneke,
A. Bürkle, T. Schwerdtle, Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response. Mol Nutr Food Res. 2013, 57, 7, 1255-69.

(75) J. Bornhorst, C. A. Wehe, S. Hüwel, U. Karst, H. J. Galla, T. Schwerdtle, Impact of manganese on and transfer across blood-brain and blood-cerebrospinal fluid barrier in vitro. J Biol Chem 2012, 287, 21, 17140-51.

(76) J. Bornhorst, F. Ebert, H. Lohren, H.-U. Humpf, U. Karst, T. Schwerdtle, Effects of manganese and arsenic species on the level of energy related nucleotides in human cells. Metallomics 2012, 4, 3, 297-306.

(77) K. Isfort, F. Ebert, J. Bornhorst, S. Sargin, R. Kardakaris, M. Pasparakis, M. Bähler, T. Schwerdtle, A. Schwab, P. Hanley, Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to C5a is PI3K- AND p38 MAPK-independent. J Biol Chem 2011, 286, 52, 44776-87.

(78) C. A. Wehe, J. Bornhorst, M. Holtkamp, M. Sperling, H. J. Galla, T. Schwerdtle, U. Karst , Fast and low sample consuming quantification of manganese in cell nutrient solutions by flow injection ICP-QMS. Metallomics 2011, 3, 12, 1291-6.

(79) J. Bornhorst, F. Ebert, A. Hartwig, B. Michalke, T. Schwerdtle, Manganese inhibits poly(ADP-ribosyl)ation in human cells: a possible mechanism behind manganese-induced toxicity? J Environ Monit 2010, 12, 11, 2062-9.

Buchkapitel

(1) K. Neth, J. Bornhorst, B. Michalke, Neurodegeneration with focus on manganese and iron speciation in “Metallomics: Analytical Techniques and Speciation Methods”, Wiley 2016, Bernhard Michalke (Editor), ISBN: 978-3-527-33969-3.

(2) S. Meyer, T. Weber, R. Haferkorn-Starke, T. Schwerdtle, J. Bornhorst, Organic metal species as risk factor for neurological diseases in “Environmental Determinants of Human Health”, Springer 2016, Jozef M Pacyna and Elisabeth G. Pacyna (Editors), ISBN 978-3-319-43142-0.

(3) M. L. Ackland, E. K. Silbergeld, J. Bornhorst, G. Dedoussis, R. R. Dietert, J. O. Nriagu,

J. M. Pacyna, J. M. Pettifor, Metals in the Environment as Risk Factors for Infectious Diseases in “ESF 16: Heavy Metals and Infectious Diseases”, Gruppe 3 , Ernst Strüngmann Forum, 2015, Jerome O. Nriagu and Eric P. Skaar (Editors), ISBN 978-0-262-02919-3.

(4) J. Bornhorst, T. Schwerdtle, DNA damage induced by manganese in “manganese in health and disease”, RSC Publishing, 2015, Michael Aschner and Lucio G. Costa (Editors), ISBN 978-1-84973-943-6.

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